Screening for thrombophilia in high-risk situations
نویسندگان
چکیده
1 Division of Developmental Medicine, University of Glasgow, UK 2 Scottish Intercollegiate Guidelines Network, Edinburgh, UK 3 Division of Cardiovascular and Medical Sciences, University of Glasgow, UK 4 Ninewells Hospital, Dundee, UK 5 Department of Medicine and Therapeutics, University of Aberdeen, UK 6 Fife Acute Hospital Trust, Fife, UK 7 Department of Obstetrics and Gynaecology, Imperial College School of Medicine, London, UK
منابع مشابه
Testing for inherited thrombophilia and consequences for antithrombotic prophylaxis in patients with venous thromboembolism and their relatives
The clinical penetrance of venous thromboembolism (VTE) susceptibility genes is variable, being lower in heterozygous carriers of factor V Leiden and prothrombin 20210A (mild thrombophilia), and higher in the rare carriers of deficiencies of antithrombin, protein C or S, and those with multiple or homozygous abnormalities (high-risk thrombophilia). The absolute risk of VTE is low, and the utili...
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a:4:{s:10:"Background";s:363:"The largest percentage of failed in vitro fertilization (IVF) cycles are due to lack of implantation. As hereditary thrombophilia can cause in placentation failure, it may have a role in recurrent IVF failure. The aim of this case-control study was to determine whether or not hereditary thrombophilia is more prevalent in women with recurrent IVF failures.";s:19:"Ma...
متن کاملThrombophilia screening: a matter of debate.
In the last ten years, several risk factors that increase the risk of venous thrombosis have been discovered. Venous thrombosis is a multicausal disease in which several risk factors, both genetic and acquired, have to occur simultaneously to cause thrombosis. This means that most individuals with single thrombophilia are asymptomatic. Although testing thrombosis patients and their relatives fo...
متن کاملRisk of thrombosis associated with oral contraceptives of women from 97 families with inherited thrombophilia: high risk of thrombosis in carriers of the G20210A mutation of the prothrombin gene.
BACKGROUND AND OBJECTIVES Oral contraceptives (OC) and inherited thrombophilia are well-known risk factors associated with venous thromboembolism (VTE). However, there are only few studies on the risk of VTE in women with inherited thrombophilia who use oral contraceptives. DESIGN AND METHODS We performed a retrospective family cohort study of 325 women belonging to 97 families with inherited...
متن کاملThrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History
Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...
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